Many patients suffer from epilepsy that cannot be controlled by current medications. Surgical removal of epileptogenic brain regions is effective in only about half of cases, and not all patients are ...

Researchers identify prochlorperazine as a potential new treatment for temporal lobe epilepsy by restoring the KCC2 chloride ...

Increasing evidence points to an association between major depressive disorders (MDDs) and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical evidence ...

The brainstem, wedged between the spinal cord and the cortex, collects sensory input and distributes it throughout the brain, where it affects all manner of cognitive processing. For example, input ...

GABAergic neurons are the main inhibitory neurons in the brain, including the brainstem. Functionally diverse and important GABAergic neurons are located in the brainstem, both within and outside the ...